Waste products are produced by all cells and the waste produced by the haem molecules is hydroxyhemopyrrolin-2-one (HPL) also known as Pyrrole . It is HPL that binds to and increases the urinary excretion of Zinc, Vitamin B6 and Biotin. People who suffer from Pyrrole Disorder produce excessive amounts of HPL resulting in these nutritional deficiencies. Pyrrole Disorder sufferers also have lower levels of the Omega 6 Fat, GLA, which is due to the requirements of Zinc and Vitamin B6 in converting alpha-Linolenic acid to GLA.Supplementation helps to to reduce HPL levels and the severity of the conditions, signs and symptoms that Pyrrole Disorder sufferers experience.
Due to the various bodily functions of Zinc, Vitamin B6 and Biotin the symptoms of Pyrrole Disorder can be quite broad and far reaching. Below is a list of some common health conditions associated with Pyrrole Disorder and the percentage of those sufferers with elevated HPL levels .
|Acute Intermittent Porphyria||100%||Down Syndrome||71%|
|Asperger’s Syndrome||46-48%||Latent Acute Intermittent Porphyria||70%|
Violent / Criminal Offenders
For a full list of conditions associated with Pyrrole Disorder please click here.
As previously mentioned the roles of Zinc, Vitamin B6 and Biotin are vast and as such there are many potential side effects associated with their deficiency. Below is a short list of some of the more common signs and symptoms associated with Pyrrole Disorder.
|Anger – explosive||Intolerance to alcohol and drugs|
|Anxiety/anxious||Lack of regular menstrual cycles|
|Delayed puberty||Morning nausea|
|Delusions||Poor morning appetite|
|Depression||Prone to stitches|
|Fatigue||Sensitivity to bright light, noise and smells|
|Emotionally unstable||Social withdrawal|
|Frequent infections||Substance abuse|
For a full list of signs and symptoms associated with Pyrrole Disorder please click here.
Read our blog on the 9 most Common Pyrrole Disorder Symptoms
For some Pyrrole Disorder sufferers they can also have multiple abnormalities in their physical appearance. Some of the more common physical appearances associated with Pyrrole Disorder are listed below.
|Acne||Overcrowding of teeth|
|Early greying of hair||Poor wound healing|
|Hypo-pigmentation of skin||Skin appears paper thin|
|Inability of skin to tan||Stretch marks|
|Lack of hair on eyebrows or eyelashes||White spots on fingernails|
For a full list of body signs associated with Pyrrole Disorder please click here.
Evidence suggests that for some sufferers, Pyrrole Disorder is a genetic condition. Research and statistics indicate that if a parent, grandparent, uncle, aunt, sister or brother suffers from Alcoholism, Bi-Polar Disorder, Schizophrenia, Major Depression or has committed Suicide, that there is a greater risk of Pyrrole Disorder in other family members.
Studies indicate that Lifestyle Factors can also play a role in driving up HPL levels, thus leading to Pyrrole Disorder.
Unfortunately with many health conditions that are untreatable by conventional medicine they are deemed not real or don't exist. Regrettably, Pyrrole Disorder falls into this bracket, mainly because there are no drugs to increase levels of Vitamin B6, Biotin or Zinc and that most doctors are not trained in nutrition. Coupled with this there is misleading information available on the web, which is written by unqualified people who don't know or understand Pyrrole Disorder. Sadly, this combination leads people to believe that Pyrrole Disorder is a myth, and as such allows them no effective treatment or a proper diagnosis of Pyrrole Disorder.
For more information on Pyroluria or Pyrrole Disorder, please refer to some of our other blogs below;
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The information provided in this blog, 'Is Pyrrole Disorder Causing You To Suffer' is of a general nature intended for educational purposes only. We make no claims to diagnose, treat, prevent, alleviate or cure illnesses or diseases with any information or product stated. With any health issue we suggest you consult your healthcare professional before undertaking any health treatment.
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