Pyroluria is known by many different names including Pyrrole Disorder, Kryptopyrrole, Kryptopyrroluria, Pyrroluria, Pyrolle Disorder, Mauve Factor and Hemepyrrole.
Pyroluria is best be described as the abnormal synthesis and metabolism of the oxygen carrying molecule haemoglobin. All cells in the body produce waste or by-products and the by-product of haemoglobin metabolism is hydroxyhemopyrrolin-2-one (HPL) also known as Pyrrole. People who suffer from Pyroluria produce excessive amounts of HPL, which binds to, increases urine excretion or inhibits the function of Vitamin B6, Zinc (1-7), Biotin (8), and the Omega 6 Fat GLA. Unfortunately for a Pyroluria sufferer HPL effectively renders these nutrients unavailable. Supplementation helps to to reduce HPL levels and the severity of the conditions, signs and symptoms that a Pyroluria sufferers experiences.
Due to the various bodily functions of Zinc, Vitamin B6 and Biotin the symptoms of Pyroluria can be quite broad and far reaching. Below is a list of some common health conditions associated with Pyroluria and the percentage of those sufferers with elevated HPL levels.
|Acute Intermittent Porphyria||100%||Down Syndrome||71%|
|Asperger’s Syndrome||46-48%||Latent Acute Intermittent Porphyria||70%|
Violent / Criminal Offenders
For a full list of conditions associated with Pyroluria please click here.
As mentioned above the roles of Zinc, Vitamin B6 and Biotin are many and as such so are the potential side effects associated with their deficiency. Below is a short list of some of the more common signs and symptoms associated with Pyroluria.
|Anger – explosive||Intolerance to alcohol and drugs|
|Anxiety/anxious||Lack of regular menstrual cycles|
|Delayed puberty||Morning nausea|
|Delusions||Poor morning appetite|
|Depression||Prone to stitches|
|Fatigue||Sensitivity to bright light, noise and smells|
|Emotionally unstable||Social withdrawal|
|Frequent infections||Substance abuse|
For a full list of signs and symptoms associated with Pyroluria please click here.
Read our blog on the 9 most Common Pyroluria Symptoms
For some Pyroluria sufferers they can also have multiple abnormalities in their physical appearance. Some of the more common physical appearances associated with Pyroluria are listed below.
|Acne||Overcrowding of teeth|
|Early greying of hair||Poor wound healing|
|Hypo-pigmentation of skin||Skin appears paper thin|
|Inability of skin to tan||Stretch marks|
|Lack of hair on eyebrows or eyelashes||White spots on fingernails|
For a full list of body signs associated with Pyroluria please click here.
Evidence suggests that for some sufferers, Pyroluria is a genetic condition. Statistics and research indicate that if a parent, grandparent, aunt, uncle, brother or sister suffers from Major Depression, Bi-Polar Disorder, Alcoholism, Schizophrenia or has Suicided, that there is a greater risk of Pyroluria in other family members.
Studies indicate that Lifestyle Factors can also play a role in driving up HPL levels, thus leading to Pyroluria.
Unfortunately with many health conditions that are untreatable by conventional medicine they are deemed not real or don't exist. Regrettably, Pyroluria falls into this bracket, mainly because there are no drugs to increase Zinc, Vitamin B6 or Biotin levels and that most doctors are not trained in nutrition. Coupled with this there is misleading information available on the web, which is written by unqualified people who don't know or understand Pyroluria. Sadly, this combination leads people to believe that Pyroluria is a myth, and as such allows them no effective treatment or a proper diagnosis of Pyroluria.
The information provided here is of a general nature intended for educational purposes only. We make no claims to diagnose, treat, prevent, alleviate or cure illnesses or diseases with any information or product stated. With any health issue we suggest you consult your healthcare professional before undertaking any health treatment.
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