Pyroluria, Pyrrole Disorder and Depression

by Greg Newson 0 Comments

Pyroluria, Pyrrole Disorder and Depression | Vitality and Wellness Centre

Pyroluria, Pyrrole Disorder and Depression

People suffering from Pyroluria or Pyrrole Disorder often endure the crippling effects of Depression, without fully understanding why. Depression can be caused by many factors, but one of the most common causes is the lack of a neurotransmitter (brain chemical) called serotonin. Serotonin is our feel good neurotransmitter and when we have adequate levels we feel positive, cheerful, content, joyful and happy with life. Conversely when those levels are lower than they should be we feel down, sad, moody, angry and of course depressed, which are many of the negative symptoms associated with Pyroluria.

To understand the connection between Pyroluria and Depression we first need to know how the body makes serotonin. The precursor of serotonin is the essential amino acid L-Tryphophan. Before tryptophan can be absorbed it needs to be cleaved from food, for which there needs to be adequate levels of stomach acid and pancreatic or digestive enzymes. Once absorbed, tryptophan is then converted to a substance called 5-Hydroxytryptophan (5HTP) and then onto serotonin. For many people this process works quiet effectively, but unfortunately for a Pyroluria sufferer this task proves difficult. Mainly because Zinc and Vitamin B6 are essential to manufacture stomach acid and convert 5HTP to serotonin. 

Serotonin Pathway - Pyroluria

Stress, Depression and Pyroluria

Not only does stress increase the levels of hydroxyhemopyrrolin-2-one the substance that depletes Zinc, Vitamin B6 and Biotin and makes Pyroluria worse. But excessive or long term stress exacerbates depression by increasing the hormone cortisol. Elevated cortisol increases the levels of tryptophan pyrrolase, which inhibits the conversion of tryptophan to serotonin and cause the destruction of available tryptophan.

Thankfully, nature has provided herbs such as St John's Wort, Withania and Ginkgo biloba to help reduce the toxic effects of stress on the body, lower cortisol levels, which helps serotonin stay in the brain longer, thus reducing the symptoms of depression and improving moods. Cortisol Calm is a non-alcoholic herbal tonic containing herbs that reduce elevated cortisol levels and calm the body.

Reduce Stress and Feel Good Promotional Banner

To gain more insight into how Pyroluria contributes to Depression please listen to this podcast.

The information provided here is of a general nature intended for educational purposes only. We make no claims to diagnose, treat, prevent, alleviate or cure illnesses or diseases with any information or product stated. With any health issue we suggest you consult your healthcare professional before undertaking any health treatment.

For more infomation on Pyroluria and depression

Please read Pyroluria, Pyrrole Disorder and the GABA Connection

I hope you found this blog post interesting and helpful. If you did please leave a comment and help to spread the knowledge by sharing on social media. 

Thanks and have a great day

Greg Newson
Greg Newson


Greg Newson is a qualified Naturopath, Western Medicine Herbalist, Nutritionist, Remedial Massage Therapist and Professional Health & Wellbeing Speaker. Greg has a passion for helping people and has been treating patients in clinical practice since 2002.

Greg is the owner of the Vitality and Wellness Centre, Lismore NSW Australia, a busy Naturopathic Clinic that cares for people suffering with any type of health complaint. He is dedicated in educating people to understand and embrace the enormous potential that natural medicine has on our long-term health and well-being. Greg is able to help people improve their health and offers in-clinic, phone and Skype health consultations as well as Guest Speaking on natural medicine and heath related topics.

Greg Newson's Qualifications: Advance Diploma Human Health Science 2001 (Charles Sturt University), Advance Diploma Remedial Massage 2002 (Health Schools Australia), Advance Diploma Western Herbal Medicine 2003 (Health Schools Australia), Bachelor Health Science 2005 (Charles Sturt University), Advance Diploma Naturopathy 2008 (Health Schools Australia), Advance Diploma Functional Nutrition 2008 (Health Schools Australia).

Greg is a member of the Australian Traditional Medicine Society (ATMS)

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