Pyroluria, Pyrrole Disorder and the GABA Connection

by Greg Newson 0 Comments

Pyroluria, Pyrrole Disorder and the GABA Connection | Vitality and Wellness Centre

Pyroluria, Pyrrole Disorder and GABA

Many people suffering with Pyroluria or Pyrrole Disorder can also be afflicted with the debilitating effects of anxiety, panic attacks, nervousness, insomnia, a racing mind and even epilepsy, without really knowing the cause. To understand why Pyroluria and Pyrrole Disorder can provoke these health issues, we need to recognise the effects on the body of two important neurotransmitters (brain chemicals) GABA and Glutamate.

The difference between GABA and Glutamate

GABA is the body's major sedating and tranqueilising neurotransmitter, which is responsible for keeping us calm and relaxed. Whereas Glutamate is the excitatory neurotransmitter, responsible for increasing alertness, attention span and learning capabilities. As a generally rule Glutamate is more active during the day and GABA is more active at night when we sleep.

Problems occur when excessive Glutamate over stimulate receptors in the brain called N-methyl-D-aspartate receptors (NMDA). The over excitation of the NMDA receptors accelerates communication between neurons within the brain, resulting in a person feeling like things are moving at 100 miles an hour and that they have lost control. 

GABA is the brains breaking system and is in charge of down regulating excess glutamate and reducing NMDA over excitation. GABA neutralises anxiety, panic attacks, nervousness and insomnia while calming an overactive mind and improving the quality and duration of sleep. GABA plays a crucial role in down regulating the hyper-excitability that occurs in the brains of epilepsy and seizure sufferers.

Symptoms of Low GABA

Symptoms of low GABA vary from person to person, below is a list of common GABA deficiency symptoms.

ADHD Insomnia
Alcoholism Low Digestive Enzymes
Anxiety Mood Disorders
Bi-Polar Disorder Motion Sickness
Convulsions Nervousness
Depression Panic Attacks
Digestive Disorders Racing Mind
Feeling Overwhelmed Seizures
Hypertension Tourettes Syndrome

Pyroluria, Pyrrole Disorder and GABA Deficiency

The amino acid L-Glutamine is the precursor to the neurotransmitter Glutamate, which under normal circumstances is converted to GABA when the body requires it. For this conversion process to effective take place a few criteria's need to be met;

  • The diet needs to be high in L-Glutamine rich foods namely, animal protein, seafood, dairy, eggs, nuts, legumes and beans.
  • There needs to be adequate levels of stomach acid, which removes L-Glutamine from it's food source. A deficiency in stomach acid can result in reflux, flatulence, burping and rancid breath. Vitamin B6 and Zinc are essential in the manufacture of stomach acid. 
  • For Glutamate to be effectively converted into GABA the enzyme Glutamate Decarboxylase is required. This enzyme is total dependant on Vitamin B6 for it's up regulation. Low levels of Vitamin B6 results in an inability to effectively convert Glutamate into GABA, leading to an over stimulation of the brain neurons due to the excessive amounts of Glutamate.

A deficiency in Zinc or Vitamin B6 can hinder the manufacture of GABA. Unfortunately these deficiencies are all to common in sufferers of Pyroluria and Pyrrole Disorder 

GABA and Glutamate Pathways

Do You Have Pyroluria Promotional Banner

How To Increase GABA Levels naturally?

There are a few options available for sufferers of Pyroluria and Pyrrole Disorder to increase GABA Levels.

    • Take a nutritional supplement like Pyrrole Support that contains the correct amounts of Zinc and Vitamin B6 required for Pyroluria and Pyrrole Disorder sufferers
    • Supplementation with GABA, may offer short term respite, but it wont fix any underlying imbalances. It is just by-passing the body’s own natural metabolic processes, which generally leads to long term supplementation. GABA requirements can vary between individuals and taking a GABA supplement can have serous repercussions on other neurotransmitters. For example too much GABA can inhibit the release of serotonin. Low serotonin leads to depression, aggressiveness, migraines, ADD and insomnia. Excessive GABA also reduces available Dopamine, which is required for learning, mood enhancement, improved memory, motivation and fluent movement.
    • A more natural approach is to supply the body the nutrients it needs manufacture GABA and modulate it as required. In our clinic we use Be-Calm to supply a balanced ratio of nutrients that the body can utilise in manufacturing GABA. Increase GABA Naturally Promotional Banner

To gain more insight into how Pyroluria contributes to low GABA please listen to this podcast.

More Info On  Pyroluria and Pyrrole Disorder

Pyroluria, Pyrrole Disorder and Depression

The Connection Between Diet and Pyroluria and Diet

Please leave a comment and help spread the knowledge

If you found this blog post interesting or helpful please leave a comment and help to spread the knowledge by sharing on social media. 

Thanks and have a great day

Greg Newson
Greg Newson


Greg Newson is a qualified Naturopath, Western Medicine Herbalist, Nutritionist, Remedial Massage Therapist and Professional Health & Wellbeing Speaker. Greg has a passion for helping people and has been treating patients in clinical practice since 2002.

Greg is the owner of the Vitality and Wellness Centre, Lismore NSW Australia, a busy Naturopathic Clinic that cares for people suffering with any type of health complaint. He is dedicated in educating people to understand and embrace the enormous potential that natural medicine has on our long-term health and well-being. Greg is able to help people improve their health and offers in-clinic, phone and Skype health consultations as well as Guest Speaking on natural medicine and heath related topics.

Greg Newson's Qualifications: Advance Diploma Human Health Science 2001 (Charles Sturt University), Advance Diploma Remedial Massage 2002 (Health Schools Australia), Advance Diploma Western Herbal Medicine 2003 (Health Schools Australia), Bachelor Health Science 2005 (Charles Sturt University), Advance Diploma Naturopathy 2008 (Health Schools Australia), Advance Diploma Functional Nutrition 2008 (Health Schools Australia).

Greg is a member of the Australian Traditional Medicine Society (ATMS)

Also in Health Matters

The Dangers of Dysbiosis | Vitality and Wellness
The Dangers of Dysbiosis 😱

by Greg Newson 0 Comments

Dysbiosis is an imbalance in the micro-organisms that reside within the intestinal tract. This occurs when there are excessive levels of detrimental organisms and lower levels of the beneficial ones. Detrimental organisms include; bacteria, parasites, worms, viruses, fungi, protozoa and amoeba's.

Read More

9 Common Causes of Diarrhoea or Loose Bowels | Vitality and Wellness Centre
9 Common Causes of Diarrhoea or Loose Bowels

by Greg Newson 0 Comments

Diarrhoea or loose stools can affect everybody from time to time, but if it is present on a daily basis the long-term health ramifications can be severe. In this blog the 9 Common Causes of Diarrhoea or Loose Bowels we discuss the causes, side-effects and how to permanently treat Diarrhoea and loose stools

Read More

Pyrrole Disorder and Pyroluria Treatment | Vitality and Wellness
Pyrrole Disorder and Pyroluria Treatment

by Greg Newson 0 Comments

For anyone who has been diagnosed with Pyroluria or Pyrrole Disorder what to do next can be confusing. Some practitioners tell patients to take xyz supplement for life and while supplementation will help the symptoms of Pyroluria and Pyrrole Disorder it won't cure the condition. At Conquering Pyroluria we believe in treating the body holistically.

Read More